Adeno-associated viral vectors: Methods for production and purification for gene therapy applications [Vectores virales adeno-asociados: Métodos de producción, purificación y aplicaciones en terapia génica]

dc.contributorMena-Enriquez, M., Instituto de Biología Molecular en Medicina Y Terapia Génica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada, Núm. 950 Col. Independencia, 44340, Guadalajara, Jal., Mexico; Flores-Contreras, L., Instituto de Biología Molecular en Medicina Y Terapia Génica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada, Núm. 950 Col. Independencia, 44340, Guadalajara, Jal., Mexico; Armendáriz-Borunda, J., Instituto de Biología Molecular en Medicina Y Terapia Génica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada, Núm. 950 Col. Independencia, 44340, Guadalajara, Jal., Mexico
dc.creatorMena-Enriquez, M.
dc.creatorFlores-Contreras, L.
dc.creatorArmendariz-Borunda, J.
dc.date.accessioned2015-11-18T23:43:32Z
dc.date.accessioned2022-11-02T14:47:14Z
dc.date.available2015-11-18T23:43:32Z
dc.date.available2022-11-02T14:47:14Z
dc.date.created2015-11-18T23:43:32Z
dc.date.issued2012
dc.identifierhttp://hdl.handle.net/20.500.12104/63052
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84874811612&partnerID=40&md5=dca270094e9f1f099e3dd1d86d4a085e
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5004100
dc.description.abstractViral vectors based on adeno-associated virus (AAV) are widely used in gene therapy protocols, because they have characteristics that make them valuable for the treatment of genetic and chronic degenerative diseases. AAV2 serotype had been the best characterized to date. However, the AAV vectors developed from other serotypes is of special interest, since they have organ-specific tropism which increases their potential for transgene delivery to target cells for performing their therapeutic effects. This article summarizes AAV generalities, methods for their production and purification. It also discusses the use of these vectors in vitro, in vivo and their application in gene therapy clinical trials.
dc.relationRevista de Investigacion Clinica
dc.relation64
dc.relation5
dc.relation487
dc.relation494
dc.relationScopus
dc.relationWOS
dc.titleAdeno-associated viral vectors: Methods for production and purification for gene therapy applications [Vectores virales adeno-asociados: Métodos de producción, purificación y aplicaciones en terapia génica]
dc.typeReview


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