Activity increase in EpoR and Epo expression by intranasal recombinant human erythropoietin (rhEpo) administration in ischemic hippocampi of adult rats

dc.contributorCasta�eda-Arellano, R., Laboratorio de Neurobiolog�a Celular, Department of Cellular and Molecular Biology, CUCBA, Universidad de Guadalajara Zapopan Jal., Mexico; Feria-Velasco, A.I., Laboratorio de Neurobiolog�a Celular, Department of Cellular and Molecular Biology, CUCBA, Universidad de Guadalajara Zapopan Jal., Mexico; Rivera-Cervantes, M.C., Laboratorio de Neurobiolog�a Celular, Department of Cellular and Molecular Biology, CUCBA, Universidad de Guadalajara Zapopan Jal., Mexico
dc.creatorCastaneda-Arellano, R.
dc.creatorFeria-Velasco, A.I.
dc.creatorRivera-Cervantes, M.C.
dc.date.accessioned2015-09-15T17:14:45Z
dc.date.accessioned2022-11-02T14:28:45Z
dc.date.available2015-09-15T17:14:45Z
dc.date.available2022-11-02T14:28:45Z
dc.date.created2015-09-15T17:14:45Z
dc.date.issued2014
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907517619&partnerID=40&md5=a1cb9490f9a36d9ac268cb3008808cc7
dc.identifierhttp://hdl.handle.net/20.500.12104/39210
dc.identifier10.1016/j.neulet.2014.09.013
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4998883
dc.description.abstractErythropoietin in the nervous system is a potential neuroprotective factor for cerebral ischemic damage due to specific-binding to the erythropoietin receptor, which is associated with survival mechanisms. However, the role of its receptor is unclear. Thus, this work assessed whether a low dose (500. UI/Kg) of intranasal recombinant human erythropoietin administered 3. h after ischemia induced changes in the activation of its receptor at the Tyr456-phosphorylated site in ischemic hippocampi in rats. The results showed that recombinant human erythropoietin after injury maintained cell survival and was associated with an increase in receptor phosphorylation at the Tyr456 site as an initial signaling step, which correlated with a neuroprotective effect. � 2014 Elsevier Ireland Ltd.
dc.relationScopus
dc.relationWOS
dc.relationNeuroscience Letters
dc.relation583
dc.relation16
dc.relation20
dc.titleActivity increase in EpoR and Epo expression by intranasal recombinant human erythropoietin (rhEpo) administration in ischemic hippocampi of adult rats
dc.typeArticle


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