Serotonin-dopamine interaction: Experimental evidence and therapeutic relevance [Interacción de la serotonina y la clopamina evidencia experimental e importancia terapéutica]

Abstract

Objective: to associate serologic response to Helicobacter pylori (Hp) among seropositive university students and their families in western Mexico. Methods: we conducted a comparative transversal study, and randomized 30 nuclear families of 14 Hp-seropositive university students and 14 Hp-seronegative university students. We carried out seropositivity measurements (IgG) to Hp using the ELISA method. An analysis was performed utilizing the chisquared and Mann-Whitney U tests, with the aid of EPI INFO 2000 and SIGMA STAT 3.2 software. Results: global seropositivity in the families of infected students was 57 vs. 13% of the relatives of non-infected students (p = 0.000002). In families of Hp-positive students we found the following frequencies: parental (father and mother) 70%; mother 71%, and siblings 42%, while for seronegative individuals incidences were: parental 17% (p = 0.00005), mother 12% (p = 0.001), and siblings 10% (p = 0.0076). Conclusions: there is a greater prevalence of antibodies against Hp in the relatives of seropositive students. Copyright " 2008 ARÁN EDICIONES, S. L.",,,,,,,,,"http://hdl.handle.net/20.500.12104/44481","http://www.scopus.com/inward/record.url?eid=2-s2.0-59449090302&partnerID=40&md5=29c2bff6ed9dcb7b72ebaf3e3413995e",,,,,,"9",,"Revista Espanola de Enfermedades Digestivas",,"540

544",,"100",,"Scopus

WOS",,,,,,"Familial seroprevalence; Familial transmission; Helicobacter pylori; University students",,,,,,"Seropositivity to Helicobacter pylori among university students and their families: A comparative cross-sectional study [Seropositividad a Helicobacter pylori entre estudiantes universitarios y sus familias. Estudio comparativo]",,"Article" "46268","123456789/35008",,"González-Burgos, I., Laboratorio de Psicobiología, División de Neurociencias, Centro de Investigación Biomédica de Occidente, Sierra Mojada 800, 44340 Guadalajara, Mexico, Laboratorio de Neurobiologia Celular, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Mexico; Feria-Velasco, A., Laboratorio de Neurobiologia Celular, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Mexico",,"Gonzalez-Burgos, I.

Feria-Velasco, A.",,"2009",,"Both serotonin and dopamine neurotransmitters play a key role in modulating synaptic transmission in the central nervous system. Such serotonin-and-dopamine-mediated modulatory activity has been shown to influence a wide variety of cerebral functions both of instrumental and cognitive nature. Some brain regions strongly involved in cognition such as the prefrontal cortex, hippocampal formation, and corpus striatum, are densely innervated by serotonergic and dopaminergic afferents, proceeding from the raphe complex, and the mesocorticolimbic or nigrostriatal systems, respectively. Learning and memory are strongly modulated by the neurotransmitter activity of serotonin and dopamine; in some cases, they interact interdependently to sustain the psychobiological organization of these cognitive processes. Learning and memory depends -at least in part- on short- or long-lasting changes of synapses taking place mainly on dendritic spines, and the modulatory influence of serotonin and dopamine occurring at synaptic level may affect the codification of mnemonic information on such spines. In this sense, several experimental models of neurotransmitter activity have shown a close association between serotonin-dopamine unbalance and cytoarchitectural changes underlying learning and memory impairments. " INNN, 2009.