Difference of hepatitis B virus genotype distribution in two groups of Mexican patients with different risk factors: High prevalence of genotype H and G

Abstract

In our previous report we speculated about the possibility that some species had high levels of spontaneous micronucleated erythrocytes (MNE) just in a juvenile stage, this is, that the MNE diminish as the reticuloendothelial system matures. Here we show this effect in species including rat, rabbit, pig, dog, cat, gray squirrel, lion, giraffe, white-tailed deer, opossum and even human. The number of spontaneous MNE that we found in 43 species is shown, and the proportions of polychromatic and normochromatic. This is our third report on spontaneous MNE in different species. We obtained 189 peripheral blood samples of mammals, birds and reptiles. From 12 species we obtained only one sample, and 16 were reported previously, but now the size of the sample has been increased. The species with the highest spontaneous MNE were the Vietnamese potbelly pig (with the highest MNE number), Bengal tiger, capuchin monkey, puma, ferret, owl, hedgehog, squirrel monkey, pig and white-tailed deer. These species could be used as monitors for genotoxic events. " 2001 Elsevier Science B.V.",,,,,,"10.1016/S1383-5718(01)00180-2",,,"http://hdl.handle.net/20.500.12104/40633","http://www.scopus.com/inward/record.url?eid=2-s2.0-0035948823&partnerID=40&md5=09a56f90ec97cf5a099c63ff2db40d56",,,,,,"01-feb",,"Mutation Research - Genetic Toxicology and Environmental Mutagenesis",,"161

167",,"494",,"Scopus

WOS",,,,,,"Ageing; Birds; Mammals; Micronucleated erythrocytes; Monitor; Peripheral blood; Reptiles; Reticuloendothelial system",,,,,,"Differences in the number of micronucleated erythrocytes among young and adult animals including humans - Spontaneous micronuclei in 43 species",,"Article" "38456","123456789/35008",,,,"Preciado Coronado, Jaime",,"1999",,,,,,,,,,"1665-0565","http://hdl.handle.net/20.500.12104/36677",,,"Español",,,,"15",,"Espiral. Estudios sobre estado y sociedad",,"225-233",,"5",,"CLASE",,,,,,,,"Sistemas económicos",,,"Ocho en la cumbre","Ocho en la cumbre: los retos de la gobernabilidad global",,"journalArticle" "44407","123456789/35008",,"Bernal Bastidas, S., Serv. Ginecol., Hosp. Univ. Guadalajara, Guadalajara, Jalisco, Mexico; Ortiz, M.J., Serv. Ginecol., Hosp. Univ. Guadalajara, Guadalajara, Jalisco, Mexico",,"Bernal Bastidas, S.

Ortiz, M.J.",,"1982",,"[No abstract available]",,,,,,,,,"http://hdl.handle.net/20.500.12104/42628","http://www.scopus.com/inward/record.url?eid=2-s2.0-0020261779&partnerID=40&md5=e61ac3ee84ca9c28a481c6cdb75471c3",,,,,,"304",,"Ginecologia y Obstetricia de Mexico",,"217

220",,"50",,"Scopus",,,,,,,,,,,,"Lymphatic metastases in stage I carcinoma of the cervix [METASTASIS LINFATICAS EN CARCINOMA DE CERVIZ ESTADIO I]",, "42407","123456789/35008",,"Sánchez, L.V., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, University of Guadalajara, Guadalajara, Mexico; Tanaka, Y., Department of Clinical Molecular Informative Medicine, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan; Maldonado, M., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, University of Guadalajara, Guadalajara, Mexico; Mizokami, M., Department of Clinical Molecular Informative Medicine, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan; Panduro, A., Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, University of Guadalajara, Guadalajara, Mexico, Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara 'Fray Antonio Alcalde', PO Box 2-500, 44280 Guadalajara Jalisco, Mexico

Panduro-Cerda, Arturo., Universidad de Guadalajara",,"Sanchez, L.V.

Tanaka, Y.

Maldonado, M.

Mizokami, M.

Panduro-Cerda, Arturo",,"2007",,"Background: Hepatitis B virus (HBV) has been classified in eight genotypes, from A to H (HBV/A to HBV/H). HBV genotypes were determined in two groups with different risk factors. Methods: Group I consisted of 42 patients with chronic and acute hepatitis and group II with 25 men who have sex with men (MSM). HBV genotypes were determined by DNA sequencing of the S-gene. Results: Both groups differed with respect to genotype distribution (p < 0.001). In group I, there were 31 (74%), 9 (21%) and 2 patients (5%) with HBV/H, HBV/D and HBV/A; respectively. In group II, HBV/H, HBV/A, and HBV/G were found in 13 (52%), 8 (32%) and 4 (16%) cases, respectively. By using an HBV/G-specific PCR, 3 more cases of HBV/G were identified in group II, rising to a total 28%. All HBV/G strains were present in coinfection with other HBV genotypes, 86% with HBV/H, and 14% with HBV/A. Conclusions: HBV/H predominated in both groups. A high frequency of HBV/G was found in MSM, which was always coinfected with HBV/H or HBV/A. Significant differences in HBV genotype distribution were also found, since HBV/D was present only in patients with liver disease, whereas HBV/G was present only in MSM. Copyright " 2007 S. Karger AG.