Availability of rhenium-188 from the alumina-based tungsten-188/Rhenium-188 generator for preparation of rhenium-188-labeled radiopharmaceuticals for cancer treatment

dc.contributorKnapp Jr., F.F., Nuclear Medicine Program, Oak Ridge National Laboratory (ORNL), Oak Ridge, TN, United States, Nuclear Medicine Group, Life Sciences Division, Oak Ridge National Laboratory (ORNL), P. O. Box 2008, Oak Ridge, TN 37830-6229, United States; Beets, A.L., Nuclear Medicine Program, Oak Ridge National Laboratory (ORNL), Oak Ridge, TN, United States; Guhlke, S., Nuclear Medicine Program, Oak Ridge National Laboratory (ORNL), Oak Ridge, TN, United States, Clinic for Nuclear Medicine, University of Bonn, Germany; Zamora, P.O., Clinic for Nuclear Medicine, University of Bonn, Germany, International Program, School of Medicine, University of Guadalajara, Guadalajara, Mexico; Bender, H., Clinic for Nuclear Medicine, University of Bonn, Germany; Palmedo, H., Clinic for Nuclear Medicine, University of Bonn, Germany; Biersack, H.-J., Clinic for Nuclear Medicine, University of Bonn, Germany
dc.creatorKnapp Jr., F.F.
dc.creatorBeets, A.L.
dc.creatorGuhlke, S.
dc.creatorZamora, P.O.
dc.creatorBender, H.
dc.creatorPalmedo, H.
dc.creatorBiersack, H.-J.
dc.date.accessioned2015-11-19T18:52:29Z
dc.date.accessioned2022-11-02T14:18:20Z
dc.date.available2015-11-19T18:52:29Z
dc.date.available2022-11-02T14:18:20Z
dc.date.created2015-11-19T18:52:29Z
dc.date.issued1997
dc.identifierhttp://hdl.handle.net/20.500.12104/67794
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-1842408972&partnerID=40&md5=290ccf0629d70bcb935ebfd3158a6e4f
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4995283
dc.description.abstractRhenium-188 (β- = 2.2 MeV; γ- = 155 keV; T(1/2) 16.9 hours) is an attractive therapeutic radioisotope which is produced from decay of the reactor-produced tungsten-188 parent (T1/2 69 days) and thus conveniently obtained on demand by elution from the alumina-based tungsten-188/rhenium-188 generator system. The rhenium-188 is obtained as sodium perrhenate by elution of the generator with 0.9% saline. The post elution use of disposable tandem, ion-exchange columns is a simple method for the concentration of rhenium-188 saline solutions with specific volumes > 500 mCi/ml. This method can also extend the useful shelf-life of the generator, which can be as long as one year. The long useful shelf-life of the generator is expected to provide rhenium-188 at very reasonable costs for routine preparation of a variety of radiopharmaceuticals for the treatment of a variety of cancers.
dc.relationAnticancer Research
dc.relation17
dc.relation3 B
dc.relation1783
dc.relation1795
dc.relationScopus
dc.titleAvailability of rhenium-188 from the alumina-based tungsten-188/Rhenium-188 generator for preparation of rhenium-188-labeled radiopharmaceuticals for cancer treatment
dc.typeArticle


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