| dc.contributor | Mendizábal-Ruiz, A.P., Universidad de Guadalajara, Mexico; Morales, J., Universidad de Guadalajara, Mexico; Castro Martinez, X., Universidad de Guadalajara, Mexico, Centro Universitario de Ciencias de la Salud, Mexico; Gutierrez Rubio, S.A., Universidad de Guadalajara, Mexico; Valdez, L., University of Colima, Mexico; Vásquez-Camacho, J.G., Instituto Mexicano Del Seguro Social, Mexico, Hospital de Especialidades, Unidad de Anatomia Patalógica, Mexico; Sanchez Corona, J., Instituto Mexicano Del Seguro Social, Mexico, Centro de Investigación, Biomédica de Occidente, División de Medicina, Molecular Sierra Mojada, 800 Guadalajara, Mexico; Moran Moguel, M.C., Centro de Investigación, Biomédica de Occidente, División de Medicina, Molecular Sierra Mojada, 800 Guadalajara, Mexico | |
| dc.description.abstract | Recent information has revealed new roles in the angiogenic processes linked to the rennin-angiotensin system. To date few studies have been done on the association between RAS genes and cancer and the majority focus mainly on angiotensin I-converting enzyme (ACE). For breast cancer there are three reports that include the angiotensin II receptor, subtype 1 (AGTR1), only one for angiotensinogen (AGT) and none for renin gene (REN). In the present study we investigate whether REN (BglI), AGT (M235T), ACE (A245T, Indel), and AGTR1 (A1166C) are associated with breast cancer. Polymorphisms were analysed by PCR and RFPLs or sequence specific assay in three groups: breast cancer, benign breast disease (BBD) and general population. REN polymorphism shows that homozygous for A allele have an increased risk for BBD. Differences in M235T genotype frequencies were significant with less heterozygous in breast cancer. With different risk values ACE indel was associated with BBD and breast cancer. Association of AGTR1 was observed only in the breast cancer group, where C allele carriers present a reduced risk. Results of this work supports previous observations on the possible involvement of this system in breast cancer but it also suggests a role in benign disease. © The Author(s) 2010. | |
