Artículo
Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m
Fecha
2018Registro en:
Teixeira, V, Cabral González, P y Porcal, W. "Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m". Arkivoc. [en línea] 2018, (5), pp. 29-38. 10 h. doi: 10.24820/ark.5550190.p010.065
1551-7004
10.24820/ark.5550190.p010.065
Autor
Teixeira, Vania
Cabral González, Pablo
Porcal, Williams
Institución
Resumen
We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry.