dc.date.accessioned2022-01-18T19:26:47Z
dc.date.available2022-01-18T19:26:47Z
dc.date.created2022-01-18T19:26:47Z
dc.date.issued2012
dc.identifierhttps://hdl.handle.net/20.500.12866/10876
dc.identifierhttps://doi.org/10.1016/j.jinf.2012.06.009
dc.description.abstractObjectives: Methicillin-resistant Staphylococcus aureus (MRSA) infections are of worldwide concern. The present study describes the antimicrobial resistance and molecular typing of methicillin-resistant and methicillin-susceptible S. aureus (MSSA) bloodstream isolates in Peru. Methods: Consecutive non-duplicate S. aureus bloodstream isolates were collected over a 15-month period (2008-2009) from seven hospitals in Lima and Callao, two contiguous cities in Peru. Detection of mecA gene, spa typing and Staphylococcal Chromosomal Cassette (SCC). mec typing were performed. Antimicrobial resistance was assessed by disk diffusion. Results: Of 338 isolates, MRSA rate was 50.0%. Among MRSA isolates (n = 169), 81.7% were associated to MLST CC5, 68.8% had spa t149/SCC. mec I, and more than 85% were co-resistant to ciprofloxacin, clindamycin, erythromycin and gentamicin; 8.9% (n = 15) were associated to MLST CC8, 14 of them had spa t148/SCC. mec IV, and more than 70% were co-resistant to ciprofloxacin, clindamycin and erythromycin. Among MSSA isolates (n = 169), there was a higher diversity of spa types (n = 56) compared to MRSA isolates (n = 17), 27.2% were associated to MLST CC8, 23.7% were resistant to erythromycin and clindamycin resistance exceeded 20%. Conclusions: MRSA rate among bloodstream isolates in Peru was 50%, with MLST CC5/t149/SCC. mec I representing the most frequent clone.
dc.languageeng
dc.publisherElsevier
dc.relationJournal of Infection
dc.relation1532-2742
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHumans
dc.subjectPeru|Latin America
dc.subjectRifampicin
dc.subjectInfant Newborn
dc.subjectNewborn
dc.subjectBacterium Detection
dc.subjectAnti-Bacterial Agents
dc.subjectBacteremia
dc.subjectBacterial Gene
dc.subjectBlood Culture
dc.subjectBacterium Isolate
dc.subjectMolecular Typing
dc.subjectMicrobial Sensitivity Tests
dc.subjectCiprofloxacin
dc.subjectGentamicin
dc.subjectChloramphenicol
dc.subjectAntibiotic Resistance
dc.subjectClindamycin
dc.subjectDrug Resistance Bacterial
dc.subjectBlood Analysis
dc.subjectErythromycin
dc.subjectMethicillin Resistant Staphylococcus Aureus
dc.subjectGenes Bacterial
dc.subjectDisk Diffusion
dc.subjectStaphylococcal Infections
dc.subjectStaphylococcus Aureus
dc.subjectBacterial Transmission
dc.subjectMolecular Typing
dc.subjectGene Identification
dc.subjectHospitals
dc.subjectMeca Gene
dc.subjectMolecular Characteristics
dc.subjectSccmec I Gene
dc.subjectSccmec IV Gene
dc.subjectStaphylococcal Protein A
dc.titleAntimicrobial resistance and molecular typing of Staphylococcus aureus bloodstream isolates from hospitals in Peru
dc.typeinfo:eu-repo/semantics/article


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