Nitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia

dc.date.accessioned2020-06-10T18:11:33Z
dc.date.available2020-06-10T18:11:33Z
dc.date.created2020-06-10T18:11:33Z
dc.date.issued2014
dc.identifierhttps://hdl.handle.net/20.500.12866/7988
dc.identifierhttps://doi.org/10.1155/2014/610474
dc.description.abstractWork at high altitude in shifts exposes humans to a new form of chronic intermittent hypoxia, with still unknown health consequences. We have established a rat model resembling this situation, which develops a milder form of right ventricular hypertrophy and pulmonary artery remodelling compared to continuous chronic exposure. We aimed to compare the alterations in pulmonary artery nitric oxide (NO) availability induced by these forms of hypoxia and the mechanisms implicated. Rats were exposed for 46 days to normoxia or hypobaric hypoxia, either continuous (CH) or intermittent (2 day shifts, CIH2x2), and assessed: NO and superoxide anion availability (fluorescent indicators and confocal microscopy); expression of phosphorylated endothelial NO synthase (eNOS).
dc.languageeng
dc.publisherHindawi
dc.relationBioMed Research International
dc.relation2314-6141
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAnimals
dc.subjectHypertrophy, Right Ventricular/metabolism/pathology
dc.subjectHypoxia/metabolism/pathology
dc.subjectMale
dc.subjectNADH, NADPH Oxidoreductases/metabolism
dc.subjectNADPH Oxidase 1
dc.subjectNitric Oxide Synthase Type III/metabolism
dc.subjectNitric Oxide/metabolism
dc.subjectPulmonary Artery/metabolism/pathology
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSuperoxides/metabolism
dc.titleNitric oxide and superoxide anion balance in rats exposed to chronic and long term intermittent hypoxia
dc.typeinfo:eu-repo/semantics/article


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