Tesis
Elaboración de microesferas a base de una matriz polimérica de quitosano cargadas con ácido acetilsalicílico utilizando el método de emulsificación.
Fecha
2021-04-01Registro en:
Pulistar Manosalvas, Jaen Pierre. (2021). Elaboración de microesferas a base de una matriz polimérica de quitosano cargadas con ácido acetilsalicílico utilizando el método de emulsificación. Escuela Superior Politécnica de Chimborazo. Riobamba.
Autor
Pulistar Manosalvas, Jaen Pierre
Resumen
The objective of the study was to elaborate chitosan microspheres loaded with acetylsalicylic acid, this study was performed in order to obtain prolonged-release pharmaceutical forms that can improve the properties of the tablets such as bioavailability and release of the active principle (AP), reducing the adverse effects caused by them. The elaboration of microspheres was made using the emulsification method, first of all, 9 initial formulations with solutions at different concentrations of the reagents were made. The study was divided into two phases, in the first, the formulation and elaboration of microspheres without loading of pa was carried out, for this, in the first place the parameters of the elaboration method were standardized and thus determine what would be the stirring speed, time and ideal drying method, to obtain microspheres with the desired characteristics, while in the second phase microspheres loaded with AP and later the AP content was determined. and the dissolution profile. The evaluation of morphology and particle size was made by optical microscopy, resulting in microspheres of size less than 1 millimeter, the percentage of encapsulation and release of AP were evaluated following the tests established in the USP for this type of pharmaceutical forms, obtaining an encapsulation percentage of 32.4% and a release percentage of 83.65%, thus complying with all the acceptance criteria established in USP39-NF34. It is concluded that Formulation F5 proved to be the best in all the parameters evaluated, therefore, the microspheres prepared are considered as prolonged-release pharmaceutical forms and with subsequent studies, they could be used in pharmacological treatment. Stability tests are recommended in future research to determine if the microspheres can be applicable to in vitro studies.