artículo científico
Association of Apolipoprotein E-e4 and Dementia Declines with Age
Fecha
2014-10Registro en:
1064-7481
10.1016/j.jagp.2014.03.008
Autor
Valerio Aguilar, Daniel
Raventós Vorst, Henriette
Schmeidler, James
Beeri, Michal S.
Mora Villalobos, Lara
Bolaños Palmieri, Patricia
Carrión Baralt, José R.
Fornaguera Trías, Jaime
Silverman, Jeremy M.
Institución
Resumen
To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample).
In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years.
Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact.
The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.