Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered

dc.date.accessioned2021-08-23T22:58:02Z
dc.date.accessioned2022-10-19T00:29:09Z
dc.date.available2021-08-23T22:58:02Z
dc.date.available2022-10-19T00:29:09Z
dc.date.created2021-08-23T22:58:02Z
dc.date.issued2017
dc.identifierhttp://hdl.handle.net/10533/252187
dc.identifier1150106
dc.identifierWOS:000408036800009
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4483450
dc.description.abstractPDGFR alpha regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis. Keywords. Author Keywords:Fibrosis
dc.description.abstractPDGFR alpha
dc.description.abstractFibro/adipogenic progenitors
dc.description.abstractMuscle regeneration
dc.description.abstractPolyadenylation KeyWords Plus:CONNECTIVE-TISSUE FIBROBLASTS
dc.description.abstractMUSCLE FIBROSIS
dc.description.abstractSKELETAL-MUSCLE
dc.description.abstractSATELLITE CELLS
dc.description.abstractPDGFR-ALPHA
dc.description.abstractMYOGENESIS
dc.description.abstractDYSTROPHY
dc.description.abstractINJURY
dc.languageeng
dc.relationhttp://www.observatoriodocente.cl/download.php?file=recursos/Perfiles_Motivacionales.pdf
dc.relationhandle/10533/111557
dc.relation10.1007/s12079-016-0372-4
dc.relationhandle/10533/111541
dc.relationhandle/10533/108045
dc.rightsinfo:eu-repo/semantics/article
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.titleFibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered
dc.typeArticulo


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