Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

dc.creatorKrasnow, Anna M.
dc.creatorFord, Marc C.
dc.creatorValdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]
dc.creatorWilson, Stephen W.
dc.creatorAttwell, David
dc.date.accessioned2021-02-03T17:54:45Z
dc.date.accessioned2022-10-18T18:42:54Z
dc.date.available2021-02-03T17:54:45Z
dc.date.available2022-10-18T18:42:54Z
dc.date.created2021-02-03T17:54:45Z
dc.date.issued2018-01
dc.identifierKrasnow, A. M., Ford, M. C., Valdivia, L. E., Wilson, S. W., & Attwell, D. (2018). Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neuroscience, 21(1), 24-28.
dc.identifier1097-6256
dc.identifiereISSN: 1546-1726
dc.identifierhttp://repositorio.umayor.cl/xmlui/handle/sibum/7333
dc.identifierhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6478117&blobtype=pdf
dc.identifierhttps://dx.doi.org/10.1038%2Fs41593-017-0031-y
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/pdf/emss-74889.pdf
dc.identifier10.1038/s41593-017-0031-y
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4455117
dc.description.abstractHow action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development.
dc.languageen_US
dc.publisherNATURE PUBLISHING GROUP
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceNature Neuroscience, 21(1), 24-28
dc.subjectSYNAPTIC VESICLE RELEASE
dc.subjectINDIVIDUAL OLIGODENDROCYTES
dc.subjectCNS
dc.subjectCELLS
dc.subjectNEURONS
dc.subjectAXONS
dc.titleRegulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
dc.typeArtículos de revistas


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