dc.creator | Krasnow, Anna M. | |
dc.creator | Ford, Marc C. | |
dc.creator | Valdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] | |
dc.creator | Wilson, Stephen W. | |
dc.creator | Attwell, David | |
dc.date.accessioned | 2021-02-03T17:54:45Z | |
dc.date.accessioned | 2022-10-18T18:42:54Z | |
dc.date.available | 2021-02-03T17:54:45Z | |
dc.date.available | 2022-10-18T18:42:54Z | |
dc.date.created | 2021-02-03T17:54:45Z | |
dc.date.issued | 2018-01 | |
dc.identifier | Krasnow, A. M., Ford, M. C., Valdivia, L. E., Wilson, S. W., & Attwell, D. (2018). Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neuroscience, 21(1), 24-28. | |
dc.identifier | 1097-6256 | |
dc.identifier | eISSN: 1546-1726 | |
dc.identifier | http://repositorio.umayor.cl/xmlui/handle/sibum/7333 | |
dc.identifier | http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6478117&blobtype=pdf | |
dc.identifier | https://dx.doi.org/10.1038%2Fs41593-017-0031-y | |
dc.identifier | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/pdf/emss-74889.pdf | |
dc.identifier | 10.1038/s41593-017-0031-y | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4455117 | |
dc.description.abstract | How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development. | |
dc.language | en_US | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Nature Neuroscience, 21(1), 24-28 | |
dc.subject | SYNAPTIC VESICLE RELEASE | |
dc.subject | INDIVIDUAL OLIGODENDROCYTES | |
dc.subject | CNS | |
dc.subject | CELLS | |
dc.subject | NEURONS | |
dc.subject | AXONS | |
dc.title | Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo | |
dc.type | Artículos de revistas | |