Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

dc.creatorValdivia, Leonardo E. [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Santiago, Chile]
dc.creatorKrasnow, Anna M.
dc.creatorFord, Marc C.
dc.creatorWilson, Stephen W.
dc.creatorAttwell, David
dc.date.accessioned2020-04-08T14:11:55Z
dc.date.accessioned2020-04-13T18:12:33Z
dc.date.accessioned2022-10-18T18:40:44Z
dc.date.available2020-04-08T14:11:55Z
dc.date.available2020-04-13T18:12:33Z
dc.date.available2022-10-18T18:40:44Z
dc.date.created2020-04-08T14:11:55Z
dc.date.created2020-04-13T18:12:33Z
dc.date.issued2018
dc.identifierKrasnow, A. M., Ford, M. C., Valdivia, L. E., Wilson, S. W., & Attwell, D. (2018). Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature neuroscience, 21(1), 24-28.
dc.identifier1097-6256
dc.identifier1546-1726
dc.identifierhttps://doi.org/10.1038/s41593-017-0031-y
dc.identifierhttp://repositorio.umayor.cl/xmlui/handle/sibum/6089
dc.identifierDOI: 10.1038/s41593-017-0031-y
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4453932
dc.description.abstractHow action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development.
dc.languageen
dc.publisherNATURE PUBLISHING GROUP
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceNat. Neurosci., ENE 2018. 21(1): p. 24-+
dc.subjectNeurosciences
dc.titleRegulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
dc.typeArtículos de revistas


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