Antibacterial noncytotoxic chitosan coatings on polytetrafluoroethylene films by plasma grafting for medical device applications

dc.creatorVaz, Juliana M.
dc.creatorTaketa, Thiago B.
dc.creatorHernandez Montelongo, Jacobo
dc.creatorFiuza, Larissa M. C. G.
dc.creatorRodrigues, Cristiano
dc.creatorBeppu, Marisa M.
dc.creatorVieira, Rodrigo S.
dc.date2022
dc.date2022-02-07T21:23:31Z
dc.date2022-02-07T21:23:31Z
dc.date.accessioned2022-10-18T14:53:33Z
dc.date.available2022-10-18T14:53:33Z
dc.identifierJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH,Vol.,,2022
dc.identifierhttps://repositoriodigital.uct.cl/handle/10925/4501
dc.identifier10.1007/s11998-021-00560-3
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4444476
dc.descriptionChitosan is an exciting alternative for the development of coating-surfaces due to its large action spectrum against pathogenic microorganisms. However, to produce a stable coating with effective antibacterial action, a compromise between deacetylation degree (DD) and molecular weight (MW) is essential. Four chitosan samples were characterized regarding Mw and DD and correlated with the minimum and bactericide concentrations against E. coli, P. aeruginosa, and S. aureus. CHI80MW (79.7% DD and 7.0 x 10(5) Da) showed the best antibacterial effect and was selected to functionalize polytetrafluoroethylene (PTFE) surfaces by plasma. CHI80MW was grafted onto the PTFE surfaces using two different spacer molecules: poly(ethylene glycol) bis (carboxymethyl) ether (PEG) and poly(ethylene-alt-maleic anhydride) (PA). PTFE-Plasma-PA-CHI80MW exhibited a coating with more attached chitosan and better antibacterial action if compared to PTFE-Plasma-PEG-CHI80MW: after 8 h, PTFE-Plasma-PEG-CHI80MW presented a bacterial reduction of 25-30% for the three bacterial strains, and PTFE-Plasma-PA-CHI80MW reduced them to 77-90%. Moreover, cytotoxicity tests showed that PTFE-Plasma-PA-CHI80MW samples were compatible with human fibroblasts.
dc.languageen
dc.publisherSPRINGER
dc.sourceJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
dc.subjectAntibacterial coating
dc.subjectChitosan' plasma-grafting
dc.subjectPTFE substrate
dc.subjectBiomedical devices
dc.titleAntibacterial noncytotoxic chitosan coatings on polytetrafluoroethylene films by plasma grafting for medical device applications


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