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        • Argentina
        • Gobierno
        • Comisión de Investigaciones Científicas (Argentina)
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        • Argentina
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        • Comisión de Investigaciones Científicas (Argentina)
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        Biological effects of argentine asbestos: mineralogical and morphological characterisation

        Registro en:
        https://digital.cic.gba.gob.ar/handle/11746/11144
        https://repositorioslatinoamericanos.uchile.cl/handle/2250/4413745
        Autor
        Lescano, Leticia
        Gandini, Norberto A.
        Marfil, Silvina Andrea
        Maiza, Pedro
        Institución
        • Comisión de Investigaciones Científicas (Argentina)
        Resumen
        Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.
        Materias
        Geología
        Asbestos
        Carcinogénesis
        Asbestosis
        Amphibole
        Chrysotile

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        Red de Repositorios Latinoamericanos
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        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
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        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
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        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018
         

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        Red de Repositorios Latinoamericanos
        + de 8.000.000 publicaciones disponibles
        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Ingreso Administradores
        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
        • Brasil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018