info:eu-repo/semantics/article
Auditory deviance detection in the human insula: An intracranial EEG study
Fecha
2019-12Registro en:
Blenkmann, Alejandro Omar; Collavini, Santiago; Lubell, James; Llorens, Anaïs; Funderud, Ingrid; et al.; Auditory deviance detection in the human insula: An intracranial EEG study; Elsevier Masson; Cortex; 121; 12-2019; 189-200
1973-8102
0010-9452
CONICET Digital
CONICET
Autor
Blenkmann, Alejandro Omar
Collavini, Santiago
Lubell, James
Llorens, Anaïs
Funderud, Ingrid
Ivanovic, Jugoslav
Larsson, Pål G.
Meling, Torstein R.
Bekinschtein, Tristán Andrés
Kochen, Sara Silvia
Endestad, Tor
Knight, Robert T.
Solbakk, Anne Kristin
Resumen
The human insula is known to be involved in auditory processing, but knowledge about its precise functional role and the underlying electrophysiology is limited. To assess its role in automatic auditory deviance detection we analyzed the EEG high frequency activity (HFA; 75–145 Hz) and ERPs from 90 intracranial insular channels across 16 patients undergoing pre-surgical intracranial monitoring for epilepsy treatment. Subjects passively listened to a stream of standard and deviant tones differing in four physical dimensions: intensity, frequency, location or time. HFA responses to auditory stimuli were found in the short and long gyri, and the anterior, superior, and inferior segments of the circular sulcus of the insular cortex. Only a subset of channels in the inferior segment of the circular sulcus of the insula showed HFA deviance detection responses, i.e., a greater and longer latency response to specific deviants relative to standards. Auditory deviancy processing was also later in the insula when compared with the superior temporal cortex. ERP results were more widespread and supported the HFA insular findings. These results provide evidence that the human insula is engaged during auditory deviance detection.