info:eu-repo/semantics/article
Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
Fecha
2015-07Registro en:
Fariña, Ana Clara; González, Marcela Aída; Scalerandi, María Victoria; Lavandera, Jimena Veronica; Bernal, Claudio Adrian; Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 7; 7-2015; 933-944
1438-7697
CONICET Digital
CONICET
Autor
Fariña, Ana Clara
González, Marcela Aída
Scalerandi, María Victoria
Lavandera, Jimena Veronica
Bernal, Claudio Adrian
Resumen
This study aimed to investigate the differential effects of trans fatty acids (TFA) on the nutritional parameters, serum and tissue triacylglycerol (TAG) levels, as well as the mechanisms involved in their regulation, in male Wistar rats fed linoleic acid-enriched (+LA) or LA-deficient (-LA) diets. The TFA effects on nutritional parameters and TAG metabolism differed depending on the dietary LA status. In the +LA+TFA diet, compared to the +LA diet, TFA did not alter the serum TAG levels despite the increased epididymal adipose tissue (EAT) lipoprotein lipase (LPL) activity and the higher hepatic TAG content associated with a lower CPT-Ia activity. Otherwise, in -LA+TFA rats versus -LA, TFA increased the serum, liver, and adipose tissue TAG levels associated with higher FAS, G6PDH, and ME enzyme activities in both liver and adipose tissue, and a reduced TAG clearance by the adipose tissue LPL enzyme. Although TFA supplementation in both -LA and +LA-rats tended to decrease the CPT-Ib activity, the muscle TAG levels were not modified. We conclude that the nutritional and metabolic TFA effects depended mainly on the changes in the FA profile induced by dietary LA and, in a lesser extent, on the specific type of isomer retained in the tissues.