info:eu-repo/semantics/article
Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
Fecha
2021-12Registro en:
Fantilli, Anabella Clara; López Villa, Sarah Daniela; Zerega, Alina; Di Cola Bucciarelli, Guadalupe; López, Luis; et al.; Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure; BioMed Central; Virology Journal; 18; 1; 12-2021; 1-6
1743-422X
1743-422X
CONICET Digital
CONICET
Autor
Fantilli, Anabella Clara
López Villa, Sarah Daniela
Zerega, Alina
Di Cola Bucciarelli, Guadalupe
López, Luis
Wassaf Martínez, Maribel
Pisano, María Belén
Ré, Viviana Elizabeth
Resumen
Background: The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liverfailure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirrhosis, which could end in the failure of one or more organs and high short-term mortality. There are scarce data about the association of HEV in patients with chronic liver disorders in South America.
Case presentation: A 56-year-old hypertensive male with a history of type 2 diabetes was diagnosed with alcoholrelated-liver cirrhosis in February 2019. A year later, the patient was admitted to hospital due to fatigue, jaundice and acholia. No evidence of hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, herpes zoster virus and cytomegalovirus infections were found. Nevertheless, in February and March, 2020 the patient was positive for HEVIgM and HEV-IgG, and HEV genotype 3 RNA was detected in sera. Afterwards, he presented grade I hepatic encephalopathy and, therefore, was diagnosed with acute hepatitis E-on-chronic liver disease. The patient reported a recent travel to the Argentine coast, where he consumed seafood. Besides, he reveled to have consumed pork meat and had no history of blood transfusion.
Conclusion: This report describes a unique case of hepatitis E virus infection in a patient with alcohol-related cirrhosis. This is the frst report of a patient with HEV-related ACLF in Argentina and it invokes the importance of HEV surveillance and treatment among patients with CLD, such as alcohol-related cirrhosis.