info:eu-repo/semantics/article
A formal total synthesis of the marine alkaloid aaptamine
Fecha
2008-05Registro en:
Larghi, Enrique Leandro; Obrist, Blaise V.; Kaufman, Teodoro Saul; A formal total synthesis of the marine alkaloid aaptamine; Pergamon-Elsevier Science Ltd; Tetrahedron; 64; 22; 5-2008; 5236-5245
0040-4020
CONICET Digital
CONICET
Autor
Larghi, Enrique Leandro
Obrist, Blaise V.
Kaufman, Teodoro Saul
Resumen
A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product.