info:eu-repo/semantics/article
A genomic catalog of Earth’s microbiomes
Fecha
2020-11Registro en:
Nayfach, Stephen; Roux, Simon; Seshadri, Rekha; Udwary, Daniel; Varghese, Neha; et al.; A genomic catalog of Earth’s microbiomes; Springer Nature Limited; Nature Biotechnology; 39; 11-2020; 499–509
1087-0156
1546-1696
CONICET Digital
CONICET
Autor
Nayfach, Stephen
Roux, Simon
Seshadri, Rekha
Udwary, Daniel
Varghese, Neha
Schulz, Frederik
Wu, Dongying
Paez-Espino, David
Chen, I-Min
Huntemann, Marcel
Palaniappan, Krishna
Ladau, Joshua
Mukherjee, Supratim
Reddy, T.B.K.
Nielsen, Torben
Kirton, Edward
Faria, José P.
Edirisinghe, Janaka N.
Henry, Christopher S.
Jungbluth, Sean P.
Chivian, Dylan
Dehal, Paramvir
Wood-Charlson, Elisha M.
Arkin, Adam P.
Tringe, Susannah G.
Visel, Axel
Abreu, Helena
Acinas, Silvia G.
Allen, Eric
Allen, Michelle A.
Andersen, Gary
Anesio, Alexandre M.
Attwood, Graeme
Avila-Magaña, Viridiana
Badis, Yacine
Bailey, Jake
Baker, Brett
Baldrian, Petr
Barton, Hazel A.
Woyke,Tanja
Mouncey, Nigel J.
Ivanova, Natalia N.
Kyrpides, Nikos C.
Eloe-Fadrosh, Emiley A.
Mac Cormack, Walter Patricio
Dionisi, Hebe Monica
Lozada, Mariana
Resumen
The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth?s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.