info:eu-repo/semantics/article
At the heart of neurological dimensionality: Cross-nosological and multimodal cardiac interoceptive deficits
Fecha
2020-11Registro en:
Abrevaya, Sofia; Fittipaldi, María Sol; García, Adolfo Martín; Dottori, Martin; Santamaria Garcia, Hernando; et al.; At the heart of neurological dimensionality: Cross-nosological and multimodal cardiac interoceptive deficits; Lippincott Williams; Psychosomatic Medicine; 82; 9; 11-2020; 850-861
0033-3174
1534-7796
CONICET Digital
CONICET
Autor
Abrevaya, Sofia
Fittipaldi, María Sol
García, Adolfo Martín
Dottori, Martin
Santamaria Garcia, Hernando
Birba, Agustina
Yoris, Adrián Isidro
Hildebrandt, Malin Katharina
Salamone, Paula Celeste
De la Fuente, Aletheia
Alarco Martí, Sofía
García Cordero, Indira Ruth
Martorell Caro, Miguel Angel
Pautassi, Ricardo Marcos
Serrano, Cecilia Mariela
Sedeño, Lucas
Ibáñez, Agustín
Resumen
Objective Neurological nosology, based on categorical systems, has largely ignored dimensional aspects of neurocognitive impairments. Transdiagnostic dimensional approaches of interoception (the sensing of visceral signals) may improve the descriptions of cross-pathological symptoms at behavioral, electrophysiological, and anatomical levels. Alterations of cardiac interoception (encompassing multidimensional variables such as accuracy, learning, sensibility, and awareness) and its neural correlates (electrophysiological markers, imaging-based anatomical and functional connectivity) have been proposed as critical across disparate neurological disorders. However, no study has examined the specific impact of neural (relative to autonomic) disturbances of cardiac interoception or their differential manifestations across neurological conditions. Methods Here, we used a computational approach to classify and evaluate which markers of cardiac interoception (behavioral, metacognitive, electrophysiological, volumetric, or functional) offer the best discrimination between neurological conditions and cardiac (hypertensive) disease (model 1), and among neurological conditions (Alzheimer's disease, frontotemporal dementia, multiple sclerosis, and brain stroke; model 2). In total, the study comprised 52 neurological patients (mean [standard deviation] age = 55.1 [17.3] years; 37 women), 25 cardiac patients (age = 66.2 [9.1] years; 13 women), and 72 healthy controls (age = 52.65 [17.1] years; 50 women). Results Cardiac interoceptive outcomes successfully classified between neurological and cardiac conditions (model 1: >80% accuracy) but not among neurological conditions (model 2: 53% accuracy). Behavioral cardiac interoceptive alterations, although present in all conditions, were powerful in differentiating between neurological and cardiac diseases. However, among neurological conditions, cardiac interoceptive deficits presented more undifferentiated and unspecific disturbances across dimensions. Conclusions Our result suggests a diffuse pattern of interoceptive alterations across neurological conditions, highlighting their potential role as dimensional, transdiagnostic markers.