info:eu-repo/semantics/article
Biology of bovine herpesvirus 5
Fecha
2010-05Registro en:
del Medico Zajac, Maria Paula; Ladelfa, Maria Fatima; Kotsias, Fiorella; Muylkens, Benoît; Thiry, Julien; et al.; Biology of bovine herpesvirus 5; Elsevier; The Veterinary Journal; 184; 2; 5-2010; 138-145
1090-0233
CONICET Digital
CONICET
Autor
del Medico Zajac, Maria Paula
Ladelfa, Maria Fatima
Kotsias, Fiorella
Muylkens, Benoît
Thiry, Julien
Thiry, Etienne
Romera, Sonia
Resumen
Bovine herpesvirus 5 (BoHV-5) is an alphaherpesvirus responsible for meningoencephalitis in young cattle and is closely antigenically and genetically related to bovine herpesvirus 1 (BoHV-1). Both viruses have common aspects in their pathogenesis: (1) they infect epithelial cells at the portal of entry and (2) they establish a latent infection in the sensory nerve ganglia, i.e., the trigeminal ganglia. However, they have different neuroinvasion and neurovirulence capacities. Only in rare cases can BoHV-1 reach the brain of infected cattle. BoHV-5 infection induces different degrees of severity of neurological disease depending on both viral and host factors. Although a case of BoHV-5 associated disease in Europe and some outbreaks in USA and Australia have been reported, the current geographical distribution of BoHV-5 infection is mainly restricted to South America, especially Brazil and Argentina. This review focuses on the genomic characteristics, pathobiology and epidemiology of BoHV-5, in order to provide information on the possible basis of alphaherpesvirus neuropathogenesis.