info:eu-repo/semantics/article
Dorsal striatum coding for the timely execution of action sequences
Fecha
2021-11Registro en:
Martínez, María Cecilia; Zold, Camila Lidia; Murer, Mario Gustavo; Belluscio, Mariano Andres; Dorsal striatum coding for the timely execution of action sequences; Cold Spring Harbor Laboratory; biorXiv; 11-2021; 1-57
2692-8205
2692-8205
CONICET Digital
CONICET
Autor
Martínez, María Cecilia
Zold, Camila Lidia
Murer, Mario Gustavo
Belluscio, Mariano Andres
Resumen
The automatic initiation of actions can be highly functional. But occasionally these actions cannot be withheld and are released at inappropriate times, impulsively. Striatal activity has been shown to participate in the timing of action sequence initiation and it has been linked to impulsivity. Using a self- initiated task, we trained adult rats to withhold a rewarded action sequence until a waiting time interval has elapsed. By analyzing neuronal activity we show that the striatal response preceding the initiation of the learned sequence is strongly modulated by the time subjects wait before eliciting the sequence. Interestingly, the modulation is steeper in adolescent rats, which show a strong prevalence of impulsive responses compared to adults. We hypothesize this anticipatory striatal activity reflects the animals? subjective reward expectation, based on the elapsed waiting time, while its steeper waiting modulation in adolescence reflects age-related differences in temporal discounting, internal urgency states or explore- exploit balance.