info:eu-repo/semantics/article
Highly enantioselective reduction of the C-C double bond of N-phenyl-2-methyl- and N-phenyl-2,3-dimethyl-maleimides by fungal strains
Fecha
2009-05Registro en:
Sortino, Maximiliano Andrés; Cechinel Filho, Valdir; Zacchino, Susana Alicia Stella; Highly enantioselective reduction of the C-C double bond of N-phenyl-2-methyl- and N-phenyl-2,3-dimethyl-maleimides by fungal strains; Pergamon-Elsevier Science Ltd; Tetrahedron: Asymmetry; 20; 5-2009; 1106-1108
0957-4166
CONICET Digital
CONICET
Autor
Sortino, Maximiliano Andrés
Cechinel Filho, Valdir
Zacchino, Susana Alicia Stella
Resumen
The CAC double bond of non-substituted and substituted maleimides were hydrogenated to the corresponding succinimides by fungal strains. 2- and 2,3-methylated-phenyl-maleimides were enantioselectively reduced to (R)-N-phenyl-3-methylsuccinimide and to trans-(R,R)-N-phenyl-2,3-dimethylsuccinimide respectively by Aspergillus niger, A. flavus and A. fumigatus (conversion 96 to 99%), Fusarium graminearum and Penicillium sp (conversion: 37 and 39%), with 99% ee.