info:eu-repo/semantics/article
Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242
Fecha
2020-06Registro en:
Wang, Fuqian; Sarotti, Ariel Marcelo; Jiang, Guangde; Huguet Tapia, José C.; Zheng, Shao Liang; et al.; Waikikiamides A-C: Complex Diketopiperazine Dimer and Diketopiperazine-Polyketide Hybrids from a Hawaiian Marine Fungal Strain Aspergillus sp. FM242; American Chemical Society; Organic Letters; 22; 11; 6-2020; 4408-4412
1523-7060
CONICET Digital
CONICET
Autor
Wang, Fuqian
Sarotti, Ariel Marcelo
Jiang, Guangde
Huguet Tapia, José C.
Zheng, Shao Liang
Wu, Xiaohua
Li, Chunshun
Ding, Yousong
Cao, Shugeng
Resumen
Waikikiamides A-C (1-3), structurally complex diketopiperazine derivatives, and putative biogenic precursors, (+)-semivioxanthin (4), notoamide F (5), and (-)-notoamide A (6), were isolated from Aspergillus sp. FM242. 1 and 2, bearing a hendecacyclic ring system, represent a novel skeleton. 3 features the first unique heterodimer of two notoamide analogs with an N-O-C bridge. Compounds 1 and 3 exhibit antiproliferative activity with IC50 values in the range of 0.56 to 1.86 μM. The gene clusters mined from the sequenced genome support their putative biosynthetic pathways.