info:eu-repo/semantics/article
Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol
Fecha
2012-10Registro en:
Lang, Karen L.; Silva, Izabella T.; Zimmermann, Lara A.; Lhullier, Cíntia; Mañalich Arana, María Victoria; et al.; Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol; Molecular Diversity Preservation International; Marine Drugs; 10; 10; 10-2012; 2254-2264
1660-3397
CONICET Digital
CONICET
Autor
Lang, Karen L.
Silva, Izabella T.
Zimmermann, Lara A.
Lhullier, Cíntia
Mañalich Arana, María Victoria
Palermo, Jorge Alejandro
Falkenberg, Miriam
Simoes, Cláudia M. O.
Schenkel, Eloir P.
Duran, Fernando Javier
Resumen
In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate. The structural elucidation of the new derivatives was based on detailed NMR and MS spectroscopic analyses. The in vitro cytotoxicity of compounds 1 to 8 was evaluated against A459 and RD tumor cell lines with CC50 values ranging from 4.93 to 41.53 μM. These results suggest that the structural modifications performed on both compounds could be considered a good strategy to obtain more active derivatives. © 2012 by the authors; licensee MDPI, Basel, Switzerland.