info:eu-repo/semantics/article
Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
Fecha
2019-03Registro en:
García Couce, Jomarien; Bada Rivero, Nancy; López Hernández, Orestes D.; Nogueira, Antonio; Caracciolo, Pablo Christian; et al.; Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery; Hindawi Publishing Corporation; International Journal of Polymer Science; 2019; 3-2019; 1-9
1687-9430
CONICET Digital
CONICET
Autor
García Couce, Jomarien
Bada Rivero, Nancy
López Hernández, Orestes D.
Nogueira, Antonio
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Ramón Hernández, José A.
Peniche, Carlos
Resumen
Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependentinterpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim ofthis research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosanmicroparticles, in simulated gastric fluid (SGF, pH = 1 2) and simulated intestinal fluid (SIF, pH = 6 8). The release ofdexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug wasachieved in 5 hours. In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably,very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied aspH-dependent coating has a potential as a site-specific delivery system.