info:eu-repo/semantics/article
Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae): HPLC-MS and GC-MS characterization and antifungal activity
Fecha
2011-09Registro en:
Agüero, María Belén; Svetaz, Laura Andrea; Sánchez, Marianela; Luna, Lorena Celina; Lima, Beatriz Viviana; et al.; Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae): HPLC-MS and GC-MS characterization and antifungal activity; Pergamon-Elsevier Science Ltd; Food and Chemical Toxicology; 49; 9; 9-2011; 1970-1978
0278-6915
1873-6351
CONICET Digital
CONICET
Autor
Agüero, María Belén
Svetaz, Laura Andrea
Sánchez, Marianela
Luna, Lorena Celina
Lima, Beatriz Viviana
López, María Liza
Zacchino, Susana Alicia Stella
Palermo, Jorge Alejandro
Wunderlin, Daniel Alberto
Feresin, Gabriela Egly
Tapia, Aníbal Alejandro
Resumen
The chemical profile and botanical origin of Andean Argentinian propolis were studied by HPLC-ESI-MS/MS and GC-MS techniques as well as the antifungal activity according to CLSI protocols. Dermatophytes and yeasts tested were strongly inhibited by propolis extracts (MICs between 31.25 and 125 μg/mL). The main antifungal compounds were: 3'methyl-nordihydroguaiaretic acid (MNDGA) 1, nordihydroguaiaretic acid (NDGA) 2 and a NDGA derivative 3, showing strong activity against Trichophyton mentagrophytes, T. rubrum and Microsporum gypseum (MICs between 15.6 and 31.25 μg/mL). The lignans 1 and 2 showed activities against clinical isolates of Candidas spp., Cryptococcus spp., T. rubrum and T. mentagrophytes (MICs and MFCs between 31.25 and 62.5 μg/mL). The lignan and volatile organic compounds (VOCs) profiles from propolis matched with those of exudates of Larrea nitida providing strong evidences on its botanical origin. These results support that Argentinian Andean propolis are a valuable natural product with potential to improve human health. Six compounds (1-6) were isolated from propolis for the first time, while compounds 1 and 3-6 were reported for first time as constituents of L. nitida Cav.