info:eu-repo/semantics/article
Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease
Fecha
2020-03Registro en:
Rios, Lizette; Campos, Emiliano Emanuel; Menon, Ramkumar; Zago, María Paola; Garg, Nisha J.; Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease; Elsevier Science; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1866; 3; 3-2020; 1-37
0925-4439
CONICET Digital
CONICET
Autor
Rios, Lizette
Campos, Emiliano Emanuel
Menon, Ramkumar
Zago, María Paola
Garg, Nisha J.
Resumen
Trypanos o ma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.