info:eu-repo/semantics/article
Clostridium perfringens epsilon toxin inhibits the gastrointestinal transit in mice
Fecha
2010-12Registro en:
Losada Eaton, D. M.; Fernandez Miyakawa, Mariano Enrique; Clostridium perfringens epsilon toxin inhibits the gastrointestinal transit in mice; Elsevier; Research in Veterinary Science; 89; 3; 12-2010; 404-408
0034-5288
CONICET Digital
CONICET
Autor
Losada Eaton, D. M.
Fernandez Miyakawa, Mariano Enrique
Resumen
Epsilon toxin produced by Clostridium perfringens type B and D is a potent toxin that is responsible for a highly fatal enterotoxemia in sheep and goats. In vitro, epsilon toxin produces contraction of the rat ileum as the result of an indirect action, presumably mediated through the autonomic nervous system. To examine the impact of epsilon toxin in the intestinal transit, gastric emptying (GE) and gastrointestinal transit (GIT) were evaluated after intravenous and oral administration of epsilon toxin in mice. Orally administered epsilon toxin produced a delay on the GIT. Inhibition of the small intestinal transit was observed as early as 1 h after the toxin was administered orally but the effects were not observed after 1 week. Epsilon toxin also produced an inhibition in GE and a delay on the GIT when relatively high toxin concentrations were given intravenously. These results indicate that epsilon toxin administered orally or intravenously to mice transitorily inhibits the GIT. The delay in the GIT induced by epsilon toxin could be relevant in the pathogenesis of C. perfringens type B and D enterotoxemia.