info:eu-repo/semantics/article
Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances
Fecha
2019-10Registro en:
Castro, María Cecilia; Villagarcía, Hernán Gonzalo; Massa, Maria Laura; Francini, Flavio; Alpha-lipoic acid and its protective role in fructose induced endocrine-metabolic disturbances; Royal Society of Chemistry; Food & Function; 10; 1; 10-2019; 16-25
2042-650X
CONICET Digital
CONICET
Autor
Castro, María Cecilia
Villagarcía, Hernán Gonzalo
Massa, Maria Laura
Francini, Flavio
Resumen
In recent decades a worldwide increase has been reported in the consumption of unhealthy high calorie diets associated with marked changes in meal nutrient composition, such as a higher intake of refined carbohydrates, which leads to the speculatation that changes in food habits have contributed to the current epidemic of obesity and type 2 diabetes. Among these refined carbohydrates, fructose has been deeply investigated and murine models of high fructose diet have emerged as useful tools to study dietary-induced insulin resistance, impaired glucose tolerance, dyslipidemia and alterations in glucose metabolism. Since oxidative stress has been demonstrated to play a key pathogenic role in the alterations described above, several lines of research have focused on the possible preventive effects of antioxidant/ redox state regulation therapy, among which alpha-lipoic acid has been extensively investigated. The following references discussed support the fact that co-administration of alpha-lipoic acid normalized the changes generated by fructose rich diets, thereby making this compound a good therapeutic tool, also administered as a food supplement, to prevent endocrine–metabolic disturbances triggered by high fructose associated with obesity and type 2 diabetes at an early stage of development (prediabetes).