info:eu-repo/semantics/article
Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny
Fecha
2013-06Registro en:
March, Samanta Mabel; Abate, Paula; Molina, Juan Carlos; Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny; Frontiers Research Foundation; Frontiers in Behavioral Neuroscience; JUN; 6-2013; 1-10
1662-5153
CONICET Digital
CONICET
Autor
March, Samanta Mabel
Abate, Paula
Molina, Juan Carlos
Resumen
Clinical and biomedical studies sustains the notion that early ontogeny is a vulnerable window to the impact of alcohol. Experiences with the drug during these stages increase latter disposition to prefer, use or abuse ethanol. This period of enhanced sensitivity to ethanol is accompanied by a high rate of activity in the central catalase system, which metabolizes ethanol in the brain. Acetaldehyde (ACD), the first oxidation product of ethanol, has been found to share many neurobehavioral effects with the drug. Cumulative evidence supports this notion in models employing adults. Nevertheless very few studies have been conducted to analyze the role of ACD in ethanol postabsorptive effects, in newborns or infant rats. In this work we review recent experimental literature that syndicates ACD as a mediator agent of reinforcing aspects of ethanol, during early ontogenetic stages. We also show a meta-analytical correlational approach that proposes how differences in the activity of brain catalase across ontogeny, could be modulating patterns of ethanol consumption.