info:eu-repo/semantics/article
Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
Fecha
2013-08Registro en:
Meini, María Rocío; Gonzalez, Lisandro Javier; Vila, Alejandro Jose; Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm; Future Medicine; Future Microbiology; 8; 8; 8-2013; 947-949
1746-0913
CONICET Digital
CONICET
Autor
Meini, María Rocío
Gonzalez, Lisandro Javier
Vila, Alejandro Jose
Resumen
Zn(II) is an essential metal ion in living organisms, playing a wide variety of roles as a structural, regulatory or catalytic cofactor in proteins, that is able to interact with approximately 10% of the entire proteome in humans [1]. As is the case for most transition metal ions, high Zn(II) levels are toxic. Therefore, organisms have developed a series of mechanisms to regulate Zn(II) concentrations and to ensure proper metal uptake by metalloproteins [2]. These mechanisms involve specific metal sensor proteins, import and export machineries that allow subcellular compartmentalization and a pool of small molecules and/or proteins that are able to bind excess Zn(II) [2]. As a result, there is rarely free Zn(II) within cells and biological fluids [3].