Mitosis in Tissue Cultures of Human Giant Cell Tumors of Bone

Abstract

In in vitro tissue cultures of human bone tumors (osteoclastomas, chondroblastomas) containing numerous multinucleated cells, the finding of tri-, quadri- and other types of multipolar mitosis has been studied. The presence of multipolar mitosis in the cultures and its role in the formation of multinucleated cells suggest the existence of a combined mechanism of mitosis and fusion for the formation of multinucleated cells in human bone tumors in in vitro tissue cultures.