info:eu-repo/semantics/article
Glycoconjugate histochemistry in the small and large intestine of normal and Solanum glaucophyllum-intoxicated rabbits
Fecha
2010-10Registro en:
Zanuzzi, Carolina Natalia; Barbeito, Claudio Gustavo; Ortíz, M. L.; Fontana, Paula Andrea; Portiansky, Enrique Leo; et al.; Glycoconjugate histochemistry in the small and large intestine of normal and Solanum glaucophyllum-intoxicated rabbits; Elsevier; Research in Veterinary Science; 89; 2; 10-2010; 214-222
0034-5288
CONICET Digital
CONICET
Autor
Zanuzzi, Carolina Natalia
Barbeito, Claudio Gustavo
Ortíz, M. L.
Fontana, Paula Andrea
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Resumen
Vitamin D participates in mineral homeostasis, immunomodulation, cell growth and differentiation. The leaves of Solanum glaucophyllum contain high levels of 1,25-dihydroxyvitamin D3 as glycoside derivatives and their chronic ingestion generates a hypervitaminosis D-like state. We analyzed changes on carbohydrate expression as a cell differentiation indicator on samples of the small and large intestine of S. glaucophyllum-intoxicated rabbits, using conventional and lectin histochemistry. Male New Zealand white rabbits were intoxicated with S. glaucophyllum during two or four weeks and killed the day after. A group of animals (" possibly recovered group" ) were intoxicated during 15. days and killed at day 45 of the beginning of the experiment. We found changes in the lectin binding pattern in the small and large intestine of the intoxicated rabbits. Some of these changes were reverted in the possibly recovered group. Vitamin D could be a new regulator factor of the intestinal glycosylation process.