info:eu-repo/semantics/article
Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease
Fecha
2021-05Registro en:
Kolliker Frers, Rodolfo Alberto; Udovin, Lucas; Otero losada, Matilde Estela; Kobiec, Tamara; Herrera, María Inés; et al.; Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease; Hindawi Publishing Corporation; Mediators of Inflammation; 2021; 5-2021; 1-20
0962-9351
CONICET Digital
CONICET
Autor
Kolliker Frers, Rodolfo Alberto
Udovin, Lucas
Otero losada, Matilde Estela
Kobiec, Tamara
Herrera, María Inés
Palacios, Jorge
Razzitte, Gabriela
Capani, Francisco
Resumen
The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, metabolic, toxic, infectious, autoimmune, developmental, or degenerative, involve direct and indirect immune-related neuroinflammation. Brain infiltrates of the innate and adaptive immune system cells appear in response to an infective or otherwise noxious agent and produce inflammatory mediators. Mediators of inflammation include local and recruited cells and signals. Processes derived from extrinsic and intrinsic CNS diseases also elicit the CNS inflammatory response. A deeper understanding of immune-related inflammation in health and disease is necessary to find potential therapeutic targets for preventing or reducing CNS damage. This review is aimed at discussing the innate and adaptive immune system functions and their roles in regulating brain cell responses in disease and homeostasis maintenance.