info:eu-repo/semantics/article
2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones
Fecha
2020-06Registro en:
Selvero, Marcel Manke; Ledesma, Gabriela Nanci; Abram, Ulrich; Schulz Lang, Ernesto; Morel, Ademir Farias; et al.; 2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones; Elsevier Science SA; Journal of Fluorine Chemistry; 234; 6-2020; 1-7
0022-1139
CONICET Digital
CONICET
Autor
Selvero, Marcel Manke
Ledesma, Gabriela Nanci
Abram, Ulrich
Schulz Lang, Ernesto
Morel, Ademir Farias
Larghi, Enrique Leandro
Resumen
The unprecedented use of 2,2,2-trifluoroethanol as reaction solvent provided a facile and convenient access to symmetrically 3,3-disubstitued quinoline-2,4-diones in moderate to excellent yields and high regioselectivity, by reaction of 4-hydroxy-2-quinolones with electrophiles like methyl iodide, as well as benzyl and allyl bromides in the presence of K2CO3. Silver (I) oxide is required to increase the yield of the methylations.