info:eu-repo/semantics/article
Physicochemical, biological and drug-release properties of gallium crosslinked alginate/nanoparticulate bioactive glass composite films
Fecha
2011-05Registro en:
Mouriño, Viviana Silvia Lourdes; Newby, P.; Pishbin, F.; Cattalini, Juan Pablo; Lucangioli, Silvia Edith; et al.; Physicochemical, biological and drug-release properties of gallium crosslinked alginate/nanoparticulate bioactive glass composite films; Royal Society of Chemistry; Soft Matter; 7; 14; 5-2011; 6705-6712
1744-683X
CONICET Digital
CONICET
Autor
Mouriño, Viviana Silvia Lourdes
Newby, P.
Pishbin, F.
Cattalini, Juan Pablo
Lucangioli, Silvia Edith
Boccaccini, Aldo Roberto
Resumen
The aim of this work was to develop biodegradable and bioactive materials with sufficient structural integrity and prophylaxis effect against infection based on alginate-bioactive glass composite. The incorporation of bioactive glass nanoparticles (NBG) into Ga-crosslinked alginate films significantly improved their mechanical properties when compared with films fabricated with micron-sized bioactive glass particles. In addition, Ga-alginate films containing NBG induced a bacteriostatic effect in vitro towards S. aureus due to the presence of Ga ions (Ga3+), whose release is controlled solely by crosslinking the ion with alginate. Biomineralization studies in simulated body fluid suggested the deposition of hydroxyapatite on the surface of the films indicating their bioactive nature. In addition, the films were shown to feature biocompatibility toward osteoblast-like cells. Thus, it was shown that Ga-crosslinked composite films possessed relevant physicochemical, biological and controlled bacteriostatic effects which make these materials promising candidates for bone tissue engineering applications.