info:eu-repo/semantics/article
Total Synthesis of Waltherione F, a Nonrutaceous 3-Methoxy-4-quinolone, Isolated from Waltheria indica L. F.
Fecha
2018-08Registro en:
Arroyo Aguilar, Abel Alfredo; Bolivar Avila, Santiago Junior; Kaufman, Teodoro Saul; Larghi, Enrique Leandro; Total Synthesis of Waltherione F, a Nonrutaceous 3-Methoxy-4-quinolone, Isolated from Waltheria indica L. F.; American Chemical Society; Organic Letters; 20; 16; 8-2018; 5058-5061
1523-7060
CONICET Digital
CONICET
Autor
Arroyo Aguilar, Abel Alfredo
Bolivar Avila, Santiago Junior
Kaufman, Teodoro Saul
Larghi, Enrique Leandro
Resumen
Waltherione F was totally synthesized in seven steps and 31% overall yield from 2-nitro-3-methylanisole without the use of protecting groups. Key steps in the sequence were a Suzuki-Miyaura coupling to attach the n-octyl chain and a microwave-promoted cyclization of an acetonyl anthranilate to give the heterocyclic core whose 3-OH was O-methylated.