info:eu-repo/semantics/publishedVersion
Singlet Spin Order Originating from Para-H2
Fecha
2020Registro en:
Münnemann, Kerstin; Buljubasich Gentiletti, Lisandro; Franzoni, Maria Belen; Singlet Spin Order Originating from Para-H2; Royal Society of Chemistry; 2020; 333-349
978-1-78801-568-4
CONICET Digital
CONICET
Autor
Münnemann, Kerstin
Buljubasich Gentiletti, Lisandro
Franzoni, Maria Belen
Resumen
Parahydrogen induced singlet spin order provides an excellent tool for many NMR/MRI applications in the natural sciences and medicine. The huge benefit of para-H2 for NMR experiments is two-fold: it represents a pure spin state that can be very efficiently used in hyperpolarization experiments, and its singlet spin order may make it long-lived because it is immune to many relaxation mechanisms. By the method of Parahydrogen Induced Polarization (PHIP), para-H2 can be introduced in certain molecules giving rise to hyperpolarized long-lived singlet spin states under favourable experimental conditions. In this chapter, the quantum mechanical properties of H2 are briefly introduced, the procedure for para-H2 enrichment is explained and the basic concept of para-H2 induced polarization (PHIP) is presented. The application of PHIP for the generation of hyperpolarized long-lived states in low and high magnetic fields is summarized. Because singlet spin states are NMR inactive, a special focus must be set on strategies for a controlled conversion of the singlet state into an NMR detectable triplet state. The advantages and disadvantages of several methods for accomplishing this goal are discussed.