info:eu-repo/semantics/article
Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells
Fecha
2008-01Registro en:
Riva, Diego Ariel; Fernández Larrosa, Pablo Nicolás; Dolcini, Guillermina Laura; Martinez Peralta, Liliana A.; Coulombie, Felix Carlos; et al.; Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells; Springer Wien; Archives of Virology; 153; 3; 1-2008; 561-565
0304-8608
CONICET Digital
CONICET
Autor
Riva, Diego Ariel
Fernández Larrosa, Pablo Nicolás
Dolcini, Guillermina Laura
Martinez Peralta, Liliana A.
Coulombie, Felix Carlos
Mersich, Susana Esther
Resumen
Since the appearance of resistance to antiretroviral treatment is unavoidable, the host cell’s transcription factor NF-kappaB is a novel HIV target. The goal of this study was to characterize the effect of two immunomodulators, curcumin (Cur) and sulfasalazine (Sul), with a protease inhibitor, indinavir (IDV), on HIV-1 persistently infected CD4+ T-cells. Viral p24 antigen production, viral infectivity (tested on MAGI cells) and viral relative infectivity (viral infectivity/p24) were analysed. When used alone, both immunomodulators were able to reduce viral infectivity. When in combination, both 10 μM IDV plus 10 μM Cur and 10 μM IDV plus 250 μM Sul showed a significant reduction in viral infectivity and viral relative infectivity when compared to the reduction produced by IDV alone. Thus, the use of immunomodulators with IDV could help to reduce HIV-1 production in persistently infected cells.