info:eu-repo/semantics/article
Patterning and Modeling Three-Dimensional Microfluidic Devices Fabricated on a Single Sheet of Paper
Fecha
2019-05Registro en:
Mora, Maria F.; Garcia, Carlos D.; Schaumburg, Federico; Kler, Pablo Alejandro; Berli, Claudio Luis Alberto; et al.; Patterning and Modeling Three-Dimensional Microfluidic Devices Fabricated on a Single Sheet of Paper; American Chemical Society; Analytical Chemistry; 5-2019
0003-2700
CONICET Digital
CONICET
Autor
Mora, Maria F.
Garcia, Carlos D.
Schaumburg, Federico
Kler, Pablo Alejandro
Berli, Claudio Luis Alberto
Hashimoto, Michinao
Carrilho, Emanuel
Resumen
This work describes a method to fabricate three-dimensional paper microfluidic devices in one step, without the need of stacking layers of paper, glue, or tape. We used a nontransparent negative photoresist that allows patterning selectively (vertically) the paper, creating systems of two or three layers, including channels. To demonstrate the capabilities of this methodology, we designed, fabricated, and tested a six-level diluter. The performance of the device was also simulated using a simple numerical model implemented in the program PETSc-FEM. The resulting μPAD is small (1.6 cm × 2.2 cm), inexpensive, requires low volumes of sample (5 μL), and is able to perform mixing and dilution in 2 min.