info:eu-repo/semantics/article
Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children
Fecha
2021-06-15Registro en:
Libster, Romina Paula; Esteban, Ignacio; Bianchi, Alejandra Silvina; Alva Grimaldi, Luciano; Dueñas, Karina; et al.; Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children; University of Chicago Press; Journal Of Infectious Diseases; 223; 12; 15-6-2021; 2072-2079
0022-1899
1537-6613
CONICET Digital
CONICET
Autor
Libster, Romina Paula
Esteban, Ignacio
Bianchi, Alejandra Silvina
Alva Grimaldi, Luciano
Dueñas, Karina
Sancillo, Andrea
Rodriguez, Andrea
Ferrero, Fernando
Stein, Katherine
Acosta, Patricio Leandro
Ferolla, Fausto Martín
Bergel, Eduardo
Caballero, Mauricio Tomás
Polack, Fernando Pedro
Pellegrino, Gustavo
Fernandez Gago, Guadalupe
Pozzolo, Cecilia
Castro, Laura
Almeida, Rodrigo Egues
Rebec, Beatriz
González, Mariela
Calvo, Mariel
Henrichsen, Julieta
Nocito, Celina
Barbero, Guillermo
Ves Losada, Juan
Bonina, Angel
Flamenco, Edgardo
Rodriguez Perez, Alberto
Kobylarz, Alicia
Raggio, Mirta
Schavlosky, Graciela
Caria, Adriana
Barboza, Edgar
Sastre, Gustavo
Resumen
Background: Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, suggesting the degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that hMPV may preferentially affect asthmatic subjects. Methods: In a population-based surveillance study in children aged <2 years admitted for severe LRTI in Argentina, nasopharyngeal aspirates were tested by RT-PCR for hMPV, RSV, influenza A, and human rhinovirus. Results: Of 3947 children, 383 (10%) were infected with hMPV. The hospitalization rate for hMPV LRTI was 2.26 per 1000 children (95% confidence interval [CI], 2.04-2.49). Thirty-nine (10.2%) patients infected with hMPV experienced life-threatening disease (LTD; 0.23 per 1000 children; 95% CI,. 16-.31/1000), and 2 died (mortality rate 0.024 per 1000; 95% CI,. 003-.086). In hMPV-infected children birth to an asthmatic mother was an increased risk for LTD (odds ratio, 4.72; 95% CI, 1.39-16.01). We observed a specific interaction between maternal asthma and hMPV infection affecting risk for LTD. Conclusions: Maternal asthma increases the risk for LTD in children <2 years old hospitalized for severe hMPV LRTI.