info:eu-repo/semantics/article
Advances in collagen, chitosan and silica biomaterials for oral tissue regeneration: From basics to clinical trials
Fecha
2016-08Registro en:
Alvarez Echazú, María Inés; Tuttolomondo, María Victoria; Foglia, María Lucía; Mebert, Andrea Mathilde; Alvarez, Gisela Solange; et al.; Advances in collagen, chitosan and silica biomaterials for oral tissue regeneration: From basics to clinical trials; Royal Society of Chemistry; Journal of Materials Chemistry B; 4; 43; 8-2016; 6913-6929
2050-750X
CONICET Digital
CONICET
Autor
Alvarez Echazú, María Inés
Tuttolomondo, María Victoria
Foglia, María Lucía
Mebert, Andrea Mathilde
Alvarez, Gisela Solange
Desimone, Martín Federico
Resumen
Different materials have distinct surface and bulk characteristics; each of them potentially useful for the treatment of a particular wound or disease. By reviewing those materials that have reached a clinical stage the reader will have a broad panorama of the possibilities a particular material can offer, regarding its ability to support fast tissue regeneration. This review covers the most recent advances made towards the development of biomaterials aimed to support regenerative processes. Indeed, we highlight key examples, from basic research to clinical trials, of biomaterials for a specific biomedical application. In this context, the focus is made on collagen, chitosan and silica which are key representatives of a protein, a polysaccharide and an inorganic material usually employed as biomaterials. Particularly, this review article presents an overview of their potential therapeutics in the treatment of disorders within the oral mucosa and tooth supporting tissues. Finally, the importance of in vivo and in vitro studies, clinical evidence studies, systematic reviews and meta-analyses as an adequate guidance for biomaterial design and development is highlighted.