info:eu-repo/semantics/article
Ultracompact states of native proteins
Fecha
2017-11Registro en:
Grille Coronel, Leandro; Acierno, Juan Pablo; Ermacora, Mario Roberto; Ultracompact states of native proteins; Elsevier Science; Biophysical Chemistry; 230; 11-2017; 36-44
0301-4622
CONICET Digital
CONICET
Autor
Grille Coronel, Leandro
Acierno, Juan Pablo
Ermacora, Mario Roberto
Resumen
A statistical analysis of circa 20,000 X-ray structures evidenced the effects of temperature of data collection on protein intramolecular distances and degree of compaction. Identical chains with data collected at cryogenic ultralow temperatures (≤160 K) showed a radius of gyration (Rg) significantly smaller than at moderate temperatures (≥240 K). Furthermore, the analysis revealed the existence of structures with a Rg significantly smaller than expected for cryogenic temperatures. In these ultracompact cases, the unusually small Rg could not be specifically attributed to any experimental parameter or crystal features. Ultracompaction involves most atoms and results in their displacement toward the center of the molecule. Ultracompact structures on average have significantly shorter van der Waals and hydrogen bonds than expected for ultralow temperature structures. In addition, the number of van der Waals contacts was larger in ultracompact than in ultralow temperature structures. The structure of these ultracompact states was analyzed in detail and the implication and possible causes of the phenomenon are discussed.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Efeito do consumo das proteínas, peptídeos e aminoácidos do soro do leite nas heat shock proteins (HSPs) e parâmetros relacionados em ratos = Effect of the intake of whey proteins, their peptides and amino acids on the heat shock proteins (HSPs) and health related parameters in rats
Moura, Carolina Soares de, 1988- -
ProNA2020 predicts protein-DNA, protein-RNA, and protein-protein binding proteins and residues from sequence
Qiu, J.; Bernhofer, M.; Heinzinger, M.; Kemper, S.; Norambuena Arenas, Tomás; Melo Ledermann, Francisco Javier; Rost, B. (2020)