info:eu-repo/semantics/article
Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity
Fecha
2019-04Registro en:
Dib, Nahir; Fernández, Luciana; Santo, Marisa; Otero, Luis Alberto; Alustiza, Fabrisio Eduardo; et al.; Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity; Elsevier Ltd; Heliyon; 5; 4; 4-2019
2405-8440
CONICET Digital
CONICET
Autor
Dib, Nahir
Fernández, Luciana
Santo, Marisa
Otero, Luis Alberto
Alustiza, Fabrisio Eduardo
Liaudat, Ana Cecilia
Bosch, Pablo
Lavaggi, M. Laura
Cerecetto, Hugo
González, Mercedes
Resumen
Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N 5 ,N 10 -dioxide. This compound possesses potential antitumoral and anti-trypanosomal activity, but its low solubility in physiological media precludes its possible application as therapeutic drug. The amino terminated dendrimers association with the active compounds as observed trough NMR studies showed that electrostatic interactions are essential in the solubilization enhancement process. The obtaining of a stable and no cytotoxic formulation makes the drug-carried association a suitable strategy for the generation of a drug delivery system for phenazine derivatives.