info:eu-repo/semantics/article
Albendazole treatment in laying hens: Egg residues and its effects on fertility and hatchability
Fecha
2018-10Registro en:
Moreno Torrejon, Laura; Bistoletti, Mariana; Fernandez, Hector; Cantón, Lucila; Ceballos, Laura; et al.; Albendazole treatment in laying hens: Egg residues and its effects on fertility and hatchability; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 41; 5; 10-2018; 726-733
0140-7783
CONICET Digital
CONICET
Autor
Moreno Torrejon, Laura
Bistoletti, Mariana
Fernandez, Hector
Cantón, Lucila
Ceballos, Laura
Cantón, Candela
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Resumen
This work characterized the egg residual concentrations of albendazole (ABZ) and its sulphoxide (ABZSO) and sulphone (ABZSO2) metabolites and evaluated their effect on egg fertility and hatchability after ABZ treatments to laying hens. Seventy hens were allocated in groups: Group-1 was the control without treatment; Group-2 received a single ABZ oral dose (10 mg/kg); Group-3, -4 and -5 were treated with ABZ in medicated feed over 7 days at 10, 40, or 80 mg kg−1 day−1, respectively. Eggs were analyzed to determine the ABZ/metabolite level by HPLC or subjected to incubation to evaluate the fertility and hatchability. Only ABZSO and ABZSO2 metabolites were quantified in egg after ABZ single oral administration with maximum concentrations of 0.47 ± 0.08 and 0.30 ± 0.07 μg/ml, respectively. ABZ and its metabolites were found in eggs after 7-day ABZ treatments. The egg residue exposure estimated as AUCs (areas under the concentration vs. time curve) were 100.5 (ABZ), 56.3 (ABZSO) and 141.3 μg hr g−1 (ABZSO2). ABZ administration did not affect the egg fertility at any dosages. Egg hatchability was not affected by ABZ treatment at 10 mg/kg in medicated feed, but it decreased when the dose was 4–8 times higher. These results should be considered when ABZ is used for deworming laying hens.