Enhanced expression of dopamine D1 and glutamate NMDA receptors in dopamine D4 receptor knockout mice

dc.creatorGan, Lu
dc.creatorFalzone, Tomas Luis
dc.creatorZhang, Kehong
dc.creatorRubinstein, Marcelo
dc.creatorBaldessarini, Ross J.
dc.creatorTarazi, Frank I.
dc.date2004-03
dc.identifierhttp://hdl.handle.net/11336/79811
dc.identifierGan, Lu; Falzone, Tomas Luis; Zhang, Kehong; Rubinstein, Marcelo; Baldessarini, Ross J.; et al.; Enhanced expression of dopamine D1 and glutamate NMDA receptors in dopamine D4 receptor knockout mice; Springer; Journal Of Molecular Neuroscience : Mn.; 22; 3; 3-2004; 167-177
dc.identifier0895-8696
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionExpression of dopamine ([DA] D1 and D2) and glutamate ([Glu], (N-methyl-D-aspartic acid [NMDA], α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid [AMPA], and kanaic acid [KA]) receptor types were analyzed autoradiographically in forebrain regions of D4 receptor knockout mice and their wild-type controls. Selective radioligand binding to D4 receptors was virtually absent in D4 receptor knockout mouse brain in contrast to significant specific D4 binding in forebrain tissue of wild-type controls. Labeling of D1 receptors was significantly increased in nucleus accumbens (NAc; 39%) and caudate putamen (CPu; 42%) of D4-knockout mice vs wild-type controls. In addition, NMDA receptor labeling was significantly increased in NAc (31%), CPu (40%), and hippocampal CA1 (21%) and CA3 (25%) regions of D 4 knockouts vs wild-type controls. No changes in D2, AMPA or KA receptors were found. The findings suggest that D1, D 4, and NMDA receptors might interact functionally and that developmental absence of D4 receptors might trigger compensatory mechanisms that enhance expression of D1 receptors in NAc and CPu, and NMDA receptors in NAc, CPu, and hippocampus. The findings also encourage cautious interpretation of results in knockout mice with targeted absence of specific genes, as complex adaptive changes not directly related to the missing gene might contribute to physiological and behavioral responses.
dc.descriptionFil: Gan, Lu. McLean Division of Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
dc.descriptionFil: Falzone, Tomas Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.descriptionFil: Zhang, Kehong. McLean Division of Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
dc.descriptionFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.descriptionFil: Baldessarini, Ross J.. McLean Division of Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
dc.descriptionFil: Tarazi, Frank I.. McLean Division of Massachusetts General Hospital; Estados Unidos. Harvard Medical School; Estados Unidos
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/14997010
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1385/JMN:22:3:167
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1385%2FJMN%3A22%3A3%3A167
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectAutoradiography
dc.subjectCaudate Putamen
dc.subjectD4-Receptor
dc.subjectDopamine Receptors
dc.subjectGenetic Knockout
dc.subjectGlutamate Receptors
dc.subjectMutant Mice
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleEnhanced expression of dopamine D1 and glutamate NMDA receptors in dopamine D4 receptor knockout mice
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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