info:eu-repo/semantics/article
Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans
Fecha
2019-07-18Registro en:
Chute, Christopher D.; DiLoreto, Elizabeth M.; Zhang, Ying K.; Reilly, Douglas K.; Rayes, Diego Hernán; et al.; Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans; Nature; Nature Communications; 10; 1; 18-7-2019; 1-13
2041-1723
CONICET Digital
CONICET
Autor
Chute, Christopher D.
DiLoreto, Elizabeth M.
Zhang, Ying K.
Reilly, Douglas K.
Rayes, Diego Hernán
Coyle, Veronica L.
Choi, Hee June
Alkema, Mark J.
Schroeder, Frank C.
Srinivasan, Jagan
Resumen
Biogenic amine neurotransmitters play a central role in metazoan biology, and both their chemical structures and cognate receptors are evolutionarily conserved. Their primary roles are in cell-to-cell signaling, as biogenic amines are not normally recruited for communication between separate individuals. Here, we show that in the nematode C. elegans, a neurotransmitter-sensing G protein-coupled receptor, TYRA-2, is required for avoidance responses to osas#9, an ascaroside pheromone that incorporates the neurotransmitter, octopamine. Neuronal ablation, cell-specific genetic rescue, and calcium imaging show that tyra-2 expression in the nociceptive neuron, ASH, is necessary and sufficient to induce osas#9 avoidance. Ectopic expression in the AWA neuron, which is generally associated with attractive responses, reverses the response to osas#9, resulting in attraction instead of avoidance behavior, confirming that TYRA-2 partakes in the sensing of osas#9. The TYRA-2/osas#9 signaling system represents an inter-organismal communication channel that evolved via co-option of a neurotransmitter and its cognate receptor.